...In addition to reversing abnormal keratinization, there is evidence that the topical retinoids may have some anti-inflammatory properties. Both adapalene (Differin®) and tretinoin have been shown to do this in different experiments. Because Retin-A has been on the market for more than 25 years, patients will frequently come in and say, "I've already used tretinoin; it didn't work." For many physicians, their first inclination is to try something else. My favorite therapy is a topical retinoid used in conjunction with a combination of benzoyl peroxide and erythromycin. ...»
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«...All forms of acne are collections of dirt, oil and bacteria that get trapped in enlarged pores or hair follicles and which are not allowed to escape through regular rinsing or washing of the face because the skin forms a small barrier over these. Everyone has dirt and oil on their face, but not everyone gets acne and certainly most don't have severe cystic acne. The problem with acne is not just that collection of dirt and oil but that barrier of skin cells as well, which shouldn't form this way over that opening. When that barrier forms that collection grows into a small bump that we call a pimple....»
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